Hybrid Senior/Executive Director, Immunology & Inflammation

Posted 2 days ago

Apply now

About the role

  • Senior/Executive Director overseeing Immunology & Inflammation projects at Orum Therapeutics. Leading project teams and providing strategic direction from discovery through clinical development.

Responsibilities

  • Lead the I&I TA; working closely with strategic thought partners, build the capability of I&I at Orum, and develop the resourcing strategy
  • In collaboration with Orum leadership, lead development of I&I corporate-level strategy and provide guidance as appropriate
  • Lead and mentor I&I Project/Program Lead(s) as the TA grows
  • Lead internal and external experts (Biology, Chemistry, DMPK, Toxicology, etc.) to achieve project/program goals as one cross-functional team
  • Drive formation of the project/program’s integrated development strategy, develop alternative strategies
  • Identify risks and develop mitigation plans
  • Oversee execution of the integrated development strategic plan
  • Ensure that the right assays, animal models and human-based ex vivo platforms are used to de-risk the projects/programs
  • Manage and monitor CRO activities to drive project momentum
  • Design robust target validation and biomarker strategies throughout the project lifecycle to drive successful transitions from pre-clinical proof-of-concept to human clinical trials
  • Identify resource gaps to meet aggressive timelines
  • Hold matrixed team members accountable to their responsibilities
  • Drive the application of immunological methods to understand disease mechanisms and therapeutic interventions
  • Serve as a key thought leader in immunology; generate new therapeutic hypotheses and guide the scientific direction of project/program efforts
  • Make data-driven decisions and pivot strategies with agility
  • Stay at the forefront of emerging science and modalities in the I&I field
  • Keep abreast of and understand competitive advancements that may influence strategic planning for Orum assets
  • Serve as the primary point of contact for external partners, scientific advisory boards, etc.
  • Represent Orum’s I&I projects/programs at major scientific conferences, with prospective partners, and in due diligence discussions
  • Foster a culture of transparency and accountability
  • Use a culture of feedback to strategically align the team
  • Proactively act as a mentor to junior project/program leads and scientists, empowering them to direct their own paths in alignment with Orum’s core values

Requirements

  • PhD or equivalent in Immunology, Cell Biology, or a related life science field
  • 12+ years of experience in the biotech/pharma industry, with at least 8 years in a cross-functional project/program team leadership role.
  • Thorough comprehension of the I&I landscape critical; experience developing therapeutics for autoimmune and inflammatory diseases is preferred
  • Deep knowledge of B cell, T cell, and innate immune cell biology, cytokine signaling, and immune tolerance
  • Experience with ADCs, TPDs, or PROTACs is highly preferred
  • Experience leading projects/programs that have successfully entered clinical development
  • Ability to translate complex science into actionable business strategies
  • Exceptional interpersonal and presentation skills; ability to communicate and influence at the executive level, and navigate complex technical debates with humility and tact.

Benefits

  • Health insurance
  • Retirement plans
  • Paid time off
  • Flexible work arrangements
  • Professional development

Job title

Senior/Executive Director, Immunology & Inflammation

Job type

Experience level

Senior

Salary

$200,000 - $280,000 per year

Degree requirement

Professional Certificate

Location requirements

Report this job

See something inaccurate? Let us know and we'll update the listing.

Report job