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EI
Hybrid Senior Director, Global HEOR, Evidence Generation
Posted last week
About the role
- Senior Director overseeing HEOR and evidence generation strategies for Encoded Therapeutics. Leading cross-functional initiatives and supporting regulatory and commercial evidence needs for a gene therapy product.
Responsibilities
- Strategic planning and implementation: Define and lead the global HEOR roadmap for ETX101, ensuring that strategies drive creation of a strong value story for ETX101 to optimize payer and HTA engagement in alignment with clinical, regulatory and commercial readiness timelines and plans.
- Integrated evidence generation: Serve as a key internal expert supporting design of Encoded’s clinical development program to maximize their utility both for regulatory authorities and payers. Design and execute specific studies, including burden-of-illness (BOI; clinical, humanistic, economic), real-world evidence, and patient preference studies. Support development and/or validation of clinically meaningful outcome measures. Oversee development of cost-utility analyses and budget impact modelling.
- Stakeholder engagement: Partner with clinical experts, the patient community, HTA bodies/payers, and other external collaborators to disseminate accurate information across channels, including publications, congresses, and symposia.
- Operational excellence: Manage vendor selection, budgets, and resource allocation for complex HEOR projects, ensuring timely completion and, in concert with Scientific Communications, high-impact delivery of abstracts, posters, and manuscripts.
- Cross-functional support: Contribute to or lead other cross-functional initiatives, as needed, including Medical Affairs, Market Access and Commercial activities (e.g. payer/HTA research, value messaging, launch roadmaps, and CoE and patient journey mapping) to ensure development of innovative approaches that address the unique opportunities and challenges of gene therapy.
- Travel domestically and internationally, as required.
Requirements
- Education: PhD, PharmD, or MD with 10–12+ years of experience in HEOR within the biotech/pharma industry.
- Deep technical knowledge of the unique value drivers for high-cost, one-time therapies and the global HTA landscape (e.g., ICER, NICE, G-BA, JCA).
- Understanding of medical terminology, statistical concepts, and the ability to oversee complex observational research studies and cost-effectiveness modelling.
- Exceptional written and verbal communication skills, capable of presenting technical data to payers, investors, and clinical experts.
- Strong project management, and proven success managing multiple complex projects simultaneously in a fast-paced environment
- Direct experience of identifying and managing consultants, agencies, or other vendors
- Excellent written and verbal communication, negotiation, and presentation skills
- Strong interpersonal skills and ability to communicate across all levels of the organization
- Familiarity with gene therapy, rare diseases, or CNS indications preferred
- Proven understanding of medical terminology and statistical concepts
Benefits
- Comprehensive benefits package, including competitive employer premium contributions
- Meaningful stock option grants
- PTO, sick time, and holiday pay
- Generous Parental Leave program
- Pre-tax medical and dependent care programs
- STD, LTD, Life and AD&D
- Professional development opportunities
- Team-building events
- Fully stocked kitchen
- Fitness center at our SF office
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