Hybrid Principal Machine Learning Scientist

at BigHat Biosciences

• Job title: Principal Machine Learning Scientist
• Job type: Full Time
• Experience level: Lead
• Salary: $233,000 - $266,000 per year
• Degree requirement: Postgraduate Degree
• Tech skills: AWS, Python, PyTorch
• Location requirements: Hybrid, San Mateo, United States

About the role

• Principal Machine Learning Scientist at BigHat Biosciences advancing ML-driven therapeutic antibody design. Implementing generative models and optimizing antibody development processes.

Responsibilities

• Design and implement the next state-of-the-art generative models of antibody sequence and structure, and predictive models of antibody properties, trained on proprietary internal datasets of thousands to millions of antibodies.
• Identify opportunities for improvement in our ML tooling, and help to set strategy for ML research, driven by a strong high-level understanding of real-world drug development challenges
• Develop, refine, and deploy *de novo* design methods for generating initial hits to challenging, therapeutically interesting targets.
• Develop multi-modality, multi-objective iterative protein sequence optimization approaches to lab-in-the-loop antibody design problems for validation and deployment in our high-throughput wet lab - at BigHat success is only declared upon synthesis of real antibodies with drug-like properties.
• Maintain an in-depth understanding of the current state-of-the-art in ML-driven protein engineering, both in the literature and at BigHat.
• Share your findings at top-tier conferences and publish in leading scientific journals to advance the field of protein engineering.
• Provide technical guidance and mentorship to other ML and data science FTEs and interns.
• Provide ML expertise and support for ongoing therapeutics programs, directly contributing to the development of new drugs.
• Collaborate with our engineering team to ensure maximal efficiency in the automated deployment of our latest models to ongoing drug development programs.
• Work closely with an interdisciplinary team of drug developers, wet lab scientists, automation specialists, data scientists, etc. to identify inefficiencies or potential improvements in BigHat’s platform, and plan and prioritize ML methods development accordingly.

Requirements

• PhD in ML/CS or in the hard sciences with 5+ years experience developing and applying novel ML methods and a strong quantitative background.
• Publications in major ML conferences and/or leading journals, or extensive demonstrable track record developing and applying novel ML in industry.
• Strong competency in Python, familiarity with PyTorch, and experience with modern software engineering best practices.
• Excellent communication skills, sufficient biomedical domain knowledge to interact effectively with diverse scientific teams.
• Enjoys a fast-paced environment and excels at executing across multiple projects.
• Familiarity with the current state-of-the-art in ML-driven protein engineering
• Nice-to-haves include experience with de novo design, NGS data, Bayesian optimization, familiarity with antibody biology and drug development, and experience training and deploying models on AWS.

Benefits

• Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
• Dental, and vision coverage through Guardian
• Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
• 401(k) with company match
• DTO, two weeks of company-wide shutdown, and 12 company holidays
• Paid parental leave