Associate Director for Data Strategy contributing to real - world evidence with advanced analytics and partnerships. Driving innovative projects in healthcare decision - making and data science in a collaborative environment.
NN
Onsite Principal Scientist – Small Molecules, Biochemistry and Biophysics
Posted yesterday
About the role
- Principal Scientist responsible for drug discovery activities within Small Molecule Research at Novo Nordisk. Leading assay development, managing CROs, and collaborating across teams globally.
Responsibilities
- Proposing and developing assays for hit identification strategies for new programs and to drive hit-to-lead and lead optimization projects
- collaborating within a cross-functional project team to improve compound potency, properties, and understanding of compound mechanism of action (MoA)
- work collaboratively through interactions across TAs within NN
- managing a number of contract research organizations (CRO) across the globe
- supporting the preparation of patents, reports, scientific publications, and serving as functional expert in supporting IND filings
- Lead functional groups for the design, development, validation, and implementation of biochemical & biophysical assays for small molecule hit ID and MoA
- Analyze, interpret, and communicate high-quality data to a multi-disciplinary project team
- Manage global CROs and external partners on a day-to-day basis to achieve project goals
- Develop and direct collaborations with external CROs performing assay development and transfer, library screening, and hit validation across projects
- Has accountability for CROs timelines and data quality
- Enhance operational efficiency and implementing best practices within Line of Business (LoB)
- Critically evaluate project data while rigorously driving data-driven Go/No-go decisions, including the identification of resource constraints and bottlenecks
- Communicate project plans/priorities to management
- Effectively communicate and collaborate across global sites
- Represent the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents
- Contribute subject matter expertise to develop the research agenda with a clear understanding of the link between scientific project goals and overall long-term business needs
- Propose new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas
Requirements
- Master’s degree with 12+ years of relevant experience, or PhD with 8+ years of relevant experience required
- 8+ years of biochemistry and enzymology industry experience preferred
- 3+ years of previous experience managing CROs preferred
- 3+ years of biochemistry & biophysics work in a hybrid model preferred
- In-depth knowledge in biochemical and biophysical assay development and validation
- Expert in enzymology, enzyme kinetics, and current assay formats for multiple enzyme classes and protein-protein-interaction targets
- Expert in steady-state and pre-steady state kinetics to determine enzyme and inhibitor mechanism of action
- Broad experience in HTS assays
- Expertise in utilizing a wide array of biochemical and biophysical technologies, including FI, FP, TR-FRET, AlphaScreen, radiometric methods, DSF, SPR, ITC, MST
- Additional Hit finding knowledge: DEL, ASMS, and fragment-based screening beneficial
- Experience developing and executing strategies to address key aspects of small molecule mechanism of action
- Expert and hands-on experience with high throughput screening and hit validation techniques
- Broad experience with automation beneficial
- Demonstrated highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical and clinical development candidates
- Impeccable attention to detail; Maintain detailed documentation
- Experienced at writing IND reports and scientific papers
- Broad experience with protein crystallography
- Knowledge and experience using corporate database (e.g. CDD Vault/Abase, Dotmatics); Experience with data fitting software
- Experience enhancing operational efficiency and implementing best practices within LoB
- Track record of innovation and impact on programs documented with co-inventorship on issued patents and/or authorship of publications in peer-reviewed journals
- Demonstrates excellent verbal and written communication skills, strong interpersonal skills with a demonstrated ability to work collaboratively on multidisciplinary teams
- Proficient in Microsoft Office suite of products (Outlook, Excel, Word, PowerPoint)
Benefits
- medical, dental and vision coverage
- life insurance
- disability insurance
- 401(k) savings plan
- flexible spending accounts
- employee assistance program
- tuition reimbursement program
- voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance
- time off pursuant to its sick time policy
- flexible vacation policy
- parental leave policy
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