Research Assistant supporting social science research initiatives at Vanderbilt University. Involves assisting with study procedures, data collection, and collaboration with research teams.
MS
Hybrid Principal Scientist – Immunology Biomarker Lead, Translational Medicine
Posted 4 months ago
About the role
- Principal Scientist serving as Immunology Biomarker Lead in clinical programs for pharmaceutical company. Building cross-functional alignment on biomarker strategies to address disease biology and clinical endpoints.
Responsibilities
- Shape and align biomarker strategies for early and late-stage clinical programs, emphasizing clear hypotheses, fit-for-purpose readouts, and decision-linked plans.
- Lead biomarker sub-teams within cross-functional development program teams and provide functional area point of view in governance interactions.
- Build alignment across stakeholders with diverse technical backgrounds, priorities, and perspectives to converge on pragmatic biomarker choices and tradeoffs as needed.
- Partner with subject matter experts to translate disease biology and drug mechanism into clinical stage biomarker plans that address key program questions and integrate diverse technical perspectives.
- Facilitate fit-for-purpose selection of innovative biomarker technologies and methodologies (e.g., immune profiling, omics, digital pathology) grounded in disease pathophysiology and aligned with therapeutic mechanism of action.
- Contribute to analysis planning and interpretation to ensure biomarker conclusions are scientifically rigorous, clinically meaningful, and clearly communicated, both internally and externally.
Requirements
- PhD (or MD/PhD) 7+ years OR MS and 10+ years OR BS and 12+ years of experience in the biotech or pharmaceutical industry, specifically in translational or biomarker sciences
- Demonstrated ability to lead through influence in highly matrixed environments driving outcomes without formal authority through scientific credibility, relationship-building, and strategic stakeholder engagement
- Strong knowledge of immune-mediated and inflammatory disease biology and clinical development, spanning at least one of the following areas: gastrointestinal/mucosal inflammation, rheumatology, dermatology
- Demonstrated experience applying biomarkers to assess drug activity and patient response to inform therapeutic decision making
- Excellent analytical, problem-solving, and communication skills, with the ability to synthesize ambiguity into clear options and recommendations as needed.
Benefits
- medical, dental, vision healthcare and other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays
- vacation
- compassionate and sick days
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